Source: Health Canada shortage reports · Updated Jul 9, 2026
Cyclophosphamide is in a widespread shortage in Canada. 4 of 10 reported products are affected, and Health Canada has designated this a Tier 3 (most serious) shortage. Manufacturers have not committed to a recovery date.
A chemotherapy medication used to treat various cancers and some autoimmune diseases.
Products affected
4 / 10
In shortage since
Jan 10, 2026
Reports on file
16
Talk to a pharmacist
Pharmacists can substitute an unaffected manufacturer's version, adjust strengths, and in most provinces adapt or renew a prescription on the spot.
Independent services, not affiliated with rxstat; referral fees may apply. Free options exist depending on your province. In an emergency call 911; free health advice at 811.
Shortage history
Shortage history (red bands = periods in shortage).
Reports by product
The DIN is printed on your prescription label.
Active shortage
CYCLOPHOSPHAMIDE FOR INJECTION USP
1000MG · POWDER FOR SOLUTION · ANDONE PHARMACEUTICAL INC
DIN 02546736 · since Feb 23, 2026, est. end Jun 19, 2026 · Demand increase for the drug.
Active shortage
CYCLOPHOSPHAMIDE FOR INJECTION USP
2000MG · POWDER FOR SOLUTION · ANDONE PHARMACEUTICAL INC
DIN 02546744 · since Feb 23, 2026, est. end Jun 19, 2026 · Demand increase for the drug.
Active shortage
PROCYTOX
2000MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241800 · since Jan 10, 2026, no end estimate · Disruption of the manufacture of the drug.
Active shortage
PROCYTOX
500MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241798 · since Feb 13, 2026, no end estimate · Disruption of the manufacture of the drug.
Anticipated
PROCYTOX
1000MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241799 · Disruption of the manufacture of the drug.
Anticipated
CYCLOPHOSPHAMIDE FOR INJECTION USP
1000MG · POWDER FOR SOLUTION · STERIMAX INC
DIN 02547686 · Demand increase for the drug.
Anticipated
CYCLOPHOSPHAMIDE FOR INJECTION USP
2000MG · POWDER FOR SOLUTION · STERIMAX INC
DIN 02547694 · Demand increase for the drug.
To be discontinued
PROCYTOX TAB 25MG
25MG · TABLET · BAXTER CORPORATION
DIN 02241795
To be discontinued
PROCYTOX
200MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241797
Resolved
PROCYTOX TAB 50MG
50MG · TABLET · BAXTER CORPORATION
DIN 02241796 · ended Dec 16, 2025 · Delay in shipping of the drug.
Resolved
PROCYTOX
2000MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241800 · ended May 2, 2024 · Release expected April 25th, 2024
Resolved
PROCYTOX
2000MG · POWDER FOR SOLUTION · BAXTER CORPORATION
DIN 02241800 · ended Feb 27, 2024 · Disruption of the manufacture of the drug.
Showing 12 of 16 reports. All reports are on file with Health Canada.
What's happening
Cyclophosphamide is currently affected by 4 active shortage reports filed with Health Canada by ANDONE PHARMACEUTICAL INC, BAXTER CORPORATION.
The reported causes are: demand increase for the drug; disruption of the manufacture of the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.
Health Canada has flagged this as a Tier 3 shortage, its most serious category, meaning the shortage has the greatest potential impact on the health system and alternatives are limited.
If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.
Cyclophosphamide is classified under “ALKYLATINGAGENTS” (ATC L01AA).
Recent changes
No changes recorded yet.
Common questions
What is Cyclophosphamide used for?
A chemotherapy medication used to treat various cancers and some autoimmune diseases.
When will Cyclophosphamide be back in stock in Canada?
Manufacturers have not provided a reliable end date. This page updates automatically as soon as an estimate is filed.
Why is Cyclophosphamide in shortage?
See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.
What can my pharmacist do about it?
Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.
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Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.
Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.