rxstat › Shortages › Estradiol

Estradiol (Climara, Estrace) shortage status

Partial shortage

Source: Health Canada shortage reports · Updated Oct 19, 2026

Also sold as: Climara, Estrace, Oesclim, Vagifem

Some Estradiol products are in shortage in Canada (7 of 24 reported products), while others remain available. Your pharmacy may be able to substitute an unaffected manufacturer. The latest estimate for affected products to return is Dec 18, 2026.

An estrogen hormone used to treat menopause symptoms such as hot flashes.

Products affected
7 / 24
In shortage since
Jul 1, 2019
Est. full return
Dec 18, 2026
Reports on file
107
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Shortage history

2023 2024 2025 2026

Shortage history (red bands = periods in shortage).

Reports by product

The DIN is printed on your prescription label.

Active shortage
ESTRADOT 75
75MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244001 · since Oct 13, 2026, est. end Dec 18, 2026 · Disruption of the manufacture of the drug.
Active shortage
ESTRADOT 37.5
37.5MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02243999 · since Oct 13, 2026, est. end Oct 30, 2026 · Disruption of the manufacture of the drug.
Active shortage
ESTRADOT 25
25MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02245676 · since Oct 13, 2026, est. end Oct 30, 2026 · Disruption of the manufacture of the drug.
Active shortage
CLIMARA 50
50MCG · PATCH · BAYER INC
DIN 02231509 · since Sep 18, 2026, est. end Dec 15, 2026 · Demand increase for the drug.
Active shortage
ESTRACE
2MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148595 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
1MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148587 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
0.5MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02225190 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Resolved
ESTRADOT 100
100MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244002 · ended Oct 13, 2026 · Demand increase for the drug.
Resolved
LUPIN-ESTRADIOL
1MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449056 · ended Sep 10, 2026 · Disruption of the manufacture of the drug.
Resolved
LUPIN-ESTRADIOL
2MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449064 · ended Sep 10, 2026 · Disruption of the manufacture of the drug.
Resolved
CLIMARA 25
25MCG · PATCH · BAYER INC
DIN 02247499 · ended Aug 28, 2026 · Demand increase for the drug.
Resolved
CLIMARA 50
50MCG · PATCH · BAYER INC
DIN 02231509 · ended Jul 29, 2026 · Demand increase for the drug.

Showing 12 of 60 reports. All reports are on file with Health Canada.

What's happening

Estradiol is currently affected by 7 active shortage reports filed with Health Canada by SANDOZ CANADA INCORPORATED, BAYER INC, ACERUS PHARMACEUTICALS CORPORATION.

The reported causes are: disruption of the manufacture of the drug; demand increase for the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.

If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.

Estradiol is classified under “ESTROGENS” (ATC G03CA).

Recent changes

Common questions

What is Estradiol used for?

An estrogen hormone used to treat menopause symptoms such as hot flashes.

When will Estradiol be back in stock in Canada?

The latest manufacturer estimate is Dec 18, 2026. Estimates are self-reported and often slip; this page updates automatically when they change.

Why is Estradiol in shortage?

See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.

What can my pharmacist do about it?

Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.

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Possible alternatives in the same class (estrogens)

Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.

Bazedoxifene Conjugated Estrogens (Duavive) Partial shortage 1 of 1 reported products affected Conjugated Estrogens (Premarin) Partial shortage 1 of 4 reported products affected

Guides: what to do when your medication is in shortage · how to read shortage reports

Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.