rxstat › Shortages › Estradiol

Estradiol (Climara, Estrace) shortage status

Widespread shortage Tier 3: critical

Source: Health Canada shortage reports · Updated Nov 9, 2026

Also sold as: Climara, Estrace, Oesclim, Vagifem

Estradiol is in a widespread shortage in Canada. 4 of 24 reported products are affected, and Health Canada has designated this a Tier 3 (most serious) shortage. The latest manufacturer estimate for full recovery is Dec 18, 2026.

An estrogen hormone used to treat menopause symptoms such as hot flashes.

Products affected
4 / 24
In shortage since
Jul 1, 2019
Est. full return
Dec 18, 2026
Reports on file
109
Talk to a pharmacist
Pharmacists can substitute an unaffected manufacturer's version, adjust strengths, and in most provinces adapt or renew a prescription on the spot.
Book a pharmacist appointment
Need your prescription switched?
When every manufacturer is affected, an online doctor can assess your situation and prescribe an alternative.
See a doctor online

Independent services, not affiliated with rxstat; referral fees may apply. Free options exist depending on your province. In an emergency call 911; free health advice at 811.

Shortage history

2023 2024 2025 2026

Shortage history (red bands = periods in shortage).

Reports by product

The DIN is printed on your prescription label.

Active shortage
ESTRADOT 75
75MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244001 · since Oct 13, 2026, est. end Dec 18, 2026 · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
2MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148595 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
1MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148587 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
0.5MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02225190 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Anticipated
ESTRADOT 37.5
37.5MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02243999 · Delay in shipping of the drug.
Anticipated
ESTRADOT 25
25MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02245676 · Delay in shipping of the drug.
Resolved
ESTRADOT 37.5
37.5MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02243999 · ended Nov 9, 2026 · Disruption of the manufacture of the drug.
Resolved
CLIMARA 50
50MCG · PATCH · BAYER INC
DIN 02231509 · ended Nov 4, 2026 · Demand increase for the drug.
Resolved
ESTRADOT 25
25MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02245676 · ended Nov 2, 2026 · Disruption of the manufacture of the drug.
Resolved
ESTRADOT 100
100MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244002 · ended Oct 13, 2026 · Demand increase for the drug.
Resolved
LUPIN-ESTRADIOL
1MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449056 · ended Sep 10, 2026 · Disruption of the manufacture of the drug.
Resolved
LUPIN-ESTRADIOL
2MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449064 · ended Sep 10, 2026 · Disruption of the manufacture of the drug.

Showing 12 of 60 reports. All reports are on file with Health Canada.

What's happening

Estradiol is currently affected by 4 active shortage reports filed with Health Canada by SANDOZ CANADA INCORPORATED, ACERUS PHARMACEUTICALS CORPORATION.

The reported cause is: disruption of the manufacture of the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.

Health Canada has flagged this as a Tier 3 shortage, its most serious category, meaning the shortage has the greatest potential impact on the health system and alternatives are limited.

If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.

Estradiol is classified under “ESTROGENS” (ATC G03CA).

Recent changes

Common questions

What is Estradiol used for?

An estrogen hormone used to treat menopause symptoms such as hot flashes.

When will Estradiol be back in stock in Canada?

The latest manufacturer estimate is Dec 18, 2026. Estimates are self-reported and often slip; this page updates automatically when they change.

Why is Estradiol in shortage?

See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.

What can my pharmacist do about it?

Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.

Email alerts

Get an email when this drug's status changes. Double opt-in, one-click unsubscribe.

Possible alternatives in the same class (estrogens)

Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.

Bazedoxifene Conjugated Estrogens (Duavive) No current shortage Conjugated Estrogens (Premarin) Shortage anticipated 0 of 5 reported products affected

Guides: what to do when your medication is in shortage · how to read shortage reports

Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.