Source: Health Canada shortage reports · Updated Jul 29, 2026
Also sold as: Climara, Estrace, Oesclim, Vagifem
Some Estradiol products are in shortage in Canada (5 of 24 reported products), while others remain available. Your pharmacy may be able to substitute an unaffected manufacturer. The latest estimate for affected products to return is Aug 28, 2026.
An estrogen hormone used to treat menopause symptoms such as hot flashes.
Products affected
5 / 24
In shortage since
Jul 1, 2019
Est. full return
Aug 28, 2026
Reports on file
101
Talk to a pharmacist
Pharmacists can substitute an unaffected manufacturer's version, adjust strengths, and in most provinces adapt or renew a prescription on the spot.
Independent services, not affiliated with rxstat; referral fees may apply. Free options exist depending on your province. In an emergency call 911; free health advice at 811.
Shortage history
Shortage history (red bands = periods in shortage).
Reports by product
The DIN is printed on your prescription label.
Active shortage
CLIMARA 50
50MCG · PATCH · BAYER INC
DIN 02231509 · since Jun 15, 2026, est. end Jul 31, 2026 · Demand increase for the drug.
Active shortage
CLIMARA 25
25MCG · PATCH · BAYER INC
DIN 02247499 · since Jun 15, 2026, est. end Aug 28, 2026 · Demand increase for the drug.
Active shortage
ESTRACE
2MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148595 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Active shortage
ESTRACE
1MG · TABLET · ACERUS PHARMACEUTICALS CORPORATION
DIN 02148587 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
DIN 02225190 · since Jul 1, 2019, no end estimate · Disruption of the manufacture of the drug.
Anticipated
ESTRADOT 100
100MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244002 · Demand increase for the drug.
Resolved
CLIMARA 75
75MCG · PATCH · BAYER INC
DIN 02247500 · ended Jul 22, 2026 · Demand increase for the drug.
Resolved
ESTRADOT 75
75MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02244001 · ended Jun 8, 2026 · Disruption of the manufacture of the drug.
Resolved
SANDOZ ESTRADIOL DERM 75
75MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02246968 · ended Jun 15, 2026 · Demand increase for the drug.
Resolved
ESTRADOT 25
25MCG · PATCH · SANDOZ CANADA INCORPORATED
DIN 02245676 · ended Jun 8, 2026 · Disruption of the manufacture of the drug.
Resolved
LUPIN-ESTRADIOL
0.5MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449048 · ended Jun 5, 2026 · Disruption of the manufacture of the drug.
Resolved
LUPIN-ESTRADIOL
1MG · TABLET · LUPIN PHARMA CANADA LIMITED
DIN 02449056 · ended Jun 8, 2026 · Disruption of the manufacture of the drug.
Showing 12 of 60 reports. All reports are on file with Health Canada.
What's happening
Estradiol is currently affected by 5 active shortage reports filed with Health Canada by BAYER INC, ACERUS PHARMACEUTICALS CORPORATION.
The reported causes are: demand increase for the drug; disruption of the manufacture of the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.
If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.
Estradiol is classified under “ESTROGENS” (ATC G03CA).
Recent changes
Jul 27, 2026
Estimated end date pushed back : Jul 24, 2026 → Jul 31, 2026
Jul 23, 2026
Shortage resolved
Jul 23, 2026
Estimated end date pushed back : Aug 20, 2026 → Aug 28, 2026
Jul 16, 2026
New report filed
Common questions
What is Estradiol used for?
An estrogen hormone used to treat menopause symptoms such as hot flashes.
When will Estradiol be back in stock in Canada?
The latest manufacturer estimate is Aug 28, 2026. Estimates are self-reported and often slip; this page updates automatically when they change.
Why is Estradiol in shortage?
See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.
What can my pharmacist do about it?
Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.
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Possible alternatives in the same class (estrogens)
Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.
Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.