rxstat › Shortages › Timolol Brimonidine

Timolol Brimonidine (Combigan) shortage status

Widespread shortage

Source: Health Canada shortage reports · Updated Jul 22, 2026

Timolol Brimonidine is in a widespread shortage in Canada. 3 of 3 reported products are affected. The latest manufacturer estimate for full recovery is Oct 2, 2026.

A combination eye drop containing two pressure-lowering medications, used to treat glaucoma.

Products affected
3 / 3
In shortage since
Dec 16, 2025
Est. full return
Oct 2, 2026
Reports on file
6
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Shortage history

2025 2026

Shortage history (red bands = periods in shortage).

Reports by product

The DIN is printed on your prescription label.

Active shortage
COMBIGAN
0.5% 0.2% · SOLUTION · ABBVIE CORPORATION
DIN 02248347 · since Apr 7, 2026, est. end Aug 28, 2026 · Demand increase for the drug.
Active shortage
APO-BRIMONIDINE-TIMOP
0.2% 0.5% · SOLUTION · APOTEX INC
DIN 02375311 · since Dec 16, 2025, est. end Oct 2, 2026 · Disruption of the manufacture of the drug.
Active shortage
JAMP BRIMONIDINE/TIMOLOL
0.2% 0.5% · SOLUTION · JAMP PHARMA CORPORATION
DIN 02531704 · since Mar 12, 2026, est. end Jul 31, 2026 · Demand increase for the drug.
Resolved
JAMP BRIMONIDINE/TIMOLOL
0.2% 0.5% · SOLUTION · JAMP PHARMA CORPORATION
DIN 02531704 · ended Apr 20, 2026 · Disruption of the manufacture of the drug.
Resolved
COMBIGAN
0.2% 0.5% · SOLUTION · ABBVIE CORPORATION
DIN 02248347 · ended Feb 11, 2026 · Demand increase for the drug.
Resolved
APO-BRIMONIDINE-TIMOP
0.5% 0.2% · SOLUTION · APOTEX INC
DIN 02375311 · ended May 9, 2024 · Disruption of the manufacture of the drug.

What's happening

Timolol Brimonidine is currently affected by 3 active shortage reports filed with Health Canada by ABBVIE CORPORATION, APOTEX INC, JAMP PHARMA CORPORATION.

The reported causes are: demand increase for the drug; disruption of the manufacture of the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.

If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.

Timolol Brimonidine is classified under “ANTIGLAUCOMA PREPARATIONS AND MIOTICS” (ATC S01ED).

Recent changes

Common questions

What is Timolol Brimonidine used for?

A combination eye drop containing two pressure-lowering medications, used to treat glaucoma.

When will Timolol Brimonidine be back in stock in Canada?

The latest manufacturer estimate is Oct 2, 2026. Estimates are self-reported and often slip; this page updates automatically when they change.

Why is Timolol Brimonidine in shortage?

See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.

What can my pharmacist do about it?

Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.

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Possible alternatives in the same class (antiglaucoma preparations and miotics)

Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.

Apraclonidine (Iopidine) No current shortage Latanoprostene Bunod (Vyzulta) No current shortage Methazolamide No current shortage Timolol Brinzolamide No current shortage Acetylcholine Chloride (Miochol-E) Partial shortage 1 of 1 reported products affected · est. return Oct 1, 2026 Bimatoprost (Vistitan) Partial shortage 1 of 2 reported products affected

Guides: what to do when your medication is in shortage · how to read shortage reports

Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.