rxstat › Shortages › Lipase Protease Amylase

Lipase Protease Amylase (Creon Minimicrospheres, Viokace) shortage status

Partial shortage

Source: Health Canada shortage reports · Updated Sep 29, 2026

Also sold as: Creon Minimicrospheres, Viokace, Cotazym Ecs, Creon Minimicrospheres Micro

Some Lipase Protease Amylase products are in shortage in Canada (2 of 10 reported products), while others remain available. Your pharmacy may be able to substitute an unaffected manufacturer. The latest estimate for affected products to return is Feb 28, 2027.

Pancreatic enzymes used to help digestion when the pancreas does not produce enough.

Products affected
2 / 10
In shortage since
Sep 21, 2026
Est. full return
Feb 28, 2027
Reports on file
96
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Pharmacists can substitute an unaffected manufacturer's version, adjust strengths, and in most provinces adapt or renew a prescription on the spot.
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Shortage history

2023 2024 2025 2026

Shortage history (red bands = periods in shortage).

Reports by product

The DIN is printed on your prescription label.

Active shortage
CREON MINIMICROSPHERES 25
25000UNIT 25500UNIT 1600UNIT · CAPSULE (DELAYED-RELEASE) · BGP PHARMA ULC
DIN 01985205 · since Sep 21, 2026, est. end Nov 10, 2026 · Disruption of the manufacture of the drug.
Active shortage
COTAZYM
40000UNIT 35000UNIT 10000UNIT · CAPSULE (IMMEDIATE-RELEASE) · ORGANON CANADA INC.
DIN 00263818 · since Sep 22, 2026, est. end Feb 28, 2027 · Demand increase for the drug.
Anticipated
COTAZYM ECS 8
10800UNIT 45000UNIT 42000UNIT · CAPSULE (DELAYED RELEASE) · ORGANON CANADA INC.
DIN 00502790 · Shortage of an active ingredient.
Anticipated
COTAZYM ECS 20
25000UNIT 100000UNIT 100000UNIT · CAPSULE (DELAYED RELEASE) · ORGANON CANADA INC.
DIN 00821373 · Shortage of an active ingredient.
Resolved
CREON MINIMICROSPHERES MICRO
5100UNIT 320UNIT 5000UNIT · GRANULES FOR SUSPENSION, DELAYED RELEASE · BGP PHARMA ULC
DIN 02445158 · ended Mar 13, 2026 · Demand increase for the drug.
Resolved
CREON MINIMICROSPHERES 35
2240UNIT 35700UNIT 35000UNIT · CAPSULE (DELAYED RELEASE) CAPSULE · BGP PHARMA ULC
DIN 02494639 · ended Sep 23, 2025 · Globally Allocated SKU
Resolved
CREON MINIMICROSPHERES 25
1600UNIT 25000UNIT 25500UNIT · CAPSULE (DELAYED RELEASE) · BGP PHARMA ULC
DIN 01985205 · ended Jul 22, 2025 · Globally Allocated SKU
Resolved
COTAZYM
35000UNIT 40000UNIT 10000UNIT · CAPSULE (IMMEDIATE RELEASE) · ORGANON CANADA INC.
DIN 00263818 · ended Apr 25, 2025 · Demand increase for the drug.
Resolved
COTAZYM
35000UNIT 40000UNIT 10000UNIT · CAPSULE (IMMEDIATE RELEASE) · ORGANON CANADA INC.
DIN 00263818 · ended Apr 8, 2025 · Disruption of the manufacture of the drug.
Resolved
CREON MINIMICROSPHERES 10
11200UNIT 10000UNIT 730UNIT · CAPSULE (DELAYED RELEASE) · BGP PHARMA ULC
DIN 02200104 · ended Dec 13, 2024 · Globally Allocated SKU
Resolved
CREON MINIMICROSPHERES 10
730UNIT 11200UNIT 10000UNIT · CAPSULE (DELAYED RELEASE) · BGP PHARMA ULC
DIN 02200104 · ended Nov 4, 2024 · Globally Allocated SKU
Resolved
CREON MINIMICROSPHERES 10
11200UNIT 10000UNIT 730UNIT · CAPSULE (DELAYED RELEASE) · BGP PHARMA ULC
DIN 02200104 · ended Aug 26, 2024 · Globally Allocated SKU

Showing 12 of 60 reports. All reports are on file with Health Canada.

What's happening

Lipase Protease Amylase is currently affected by 2 active shortage reports filed with Health Canada by BGP PHARMA ULC, ORGANON CANADA INC..

The reported causes are: disruption of the manufacture of the drug; demand increase for the drug. Manufacturers must report shortages, but end-date estimates are their own projections and often move.

If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.

Lipase Protease Amylase is classified under “DIGESTIVES, INCL ENZYMES” (ATC A09AA).

Recent changes

Common questions

What is Lipase Protease Amylase used for?

Pancreatic enzymes used to help digestion when the pancreas does not produce enough.

When will Lipase Protease Amylase be back in stock in Canada?

The latest manufacturer estimate is Feb 28, 2027. Estimates are self-reported and often slip; this page updates automatically when they change.

Why is Lipase Protease Amylase in shortage?

See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.

What can my pharmacist do about it?

Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.

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Guides: what to do when your medication is in shortage · how to read shortage reports

Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.