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Avalglucosidase Alfa (Nexviazyme) shortage status

Partial shortage

Source: Health Canada shortage reports · Updated Jul 27, 2026

Some Avalglucosidase Alfa products are in shortage in Canada (1 of 1 reported products), while others remain available. Your pharmacy may be able to substitute an unaffected manufacturer. The latest estimate for affected products to return is Aug 25, 2026.

An enzyme replacement therapy used to treat Pompe disease.

Products affected
1 / 1
In shortage since
Jun 29, 2026
Est. full return
Aug 25, 2026
Reports on file
1
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Pharmacists can substitute an unaffected manufacturer's version, adjust strengths, and in most provinces adapt or renew a prescription on the spot.
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Reports by product

Active shortage
NEXVIAZYME
100MG · POWDER FOR SOLUTION · SANOFI-AVENTIS CANADA INC
DIN 02522365 · since Jun 29, 2026, est. end Aug 25, 2026

What's happening

Avalglucosidase Alfa is currently affected by an active shortage report filed with Health Canada by SANOFI-AVENTIS CANADA INC.

If your usual product is affected, a pharmacist is the fastest route to a solution: they can dispense an unaffected manufacturer's equivalent when one exists, and in most provinces can adapt doses or substitute a therapeutic alternative without a new appointment.

Recent changes

Common questions

What is Avalglucosidase Alfa used for?

An enzyme replacement therapy used to treat Pompe disease.

When will Avalglucosidase Alfa be back in stock in Canada?

The latest manufacturer estimate is Aug 25, 2026. Estimates are self-reported and often slip; this page updates automatically when they change.

Why is Avalglucosidase Alfa in shortage?

See the reports above; manufacturers must state a reason (most commonly manufacturing disruption or a surge in demand) when filing with Health Canada.

What can my pharmacist do about it?

Often quite a lot: substitute an equivalent product from an unaffected manufacturer, adjust quantities, or in most provinces adapt or renew prescriptions on the spot. Call your pharmacy before visiting, and call 811 for free health advice.

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Possible alternatives in the same class

Drugs in the same therapeutic class, best-supplied first. These are not automatic substitutes: only your pharmacist or prescriber can judge whether a switch makes sense for you.

Betaine (Cystadane) No current shortage Miglustat (Zavesca) No current shortage Nitisinone No current shortage Sapropterin Dihydrochloride (Kuvan) Discontinued 0 of 1 reported products affected Taliglucerase Alfa (Elelyso) Discontinued 0 of 1 reported products affected

Guides: what to do when your medication is in shortage · how to read shortage reports

Data reflects reports manufacturers are legally required to file with Health Canada, republished with per-drug aggregation by rxstat. Estimated end dates are supplied by manufacturers and frequently change. This page describes drug supply only and is not medical advice; never stop or switch a medication without speaking to your pharmacist or prescriber.